In total, five people were shot during the wee hours of Saturday morning, including the two who died. The outburst of violence prompted Minneapolis Police Chief Janeé Harteau to "urge people to put their guns down."
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"The late evening hours of July 4th and the early morning hours of July 5th were particularly violent in our city," Harteau says in a statement. "Our officers responded quickly and professionally. We take these incidents very seriously and are working diligently to apprehend those responsible for these senseless deaths."
"It is important for the residents of Minneapolis to know that the two homicides we are investigating are not random and are in no way related," she continues. "Having said that, we are concerned about the level of violence and urge people to put their guns down and find another way to resolve personal conflicts."
Mayor Betsy Hodges asked people to pray:
Pray 4 all of those affected by these tragedies. Let us also continue to do the footwork to make sure we all stay safe now & in the future.
The second incident occurred just before 5 a.m. on the 2600 block of North Third Street. That shooting left 24-year-old Francesca DeSandre dead and another woman with "serious injuries," police say.
MPD spokesman Scott Seroka tells us that despite their proximity in location and time, Minneapolis's four most recent homicides "all seem to be isolated incidents, unrelated situations."
"The belief of investigators is that the suspects and victims knew each other," Seroka says.
There were 36 murders in Minneapolis last year, down from 40 in 2012.
Send your story tips to the author, Aaron Rupar. Follow him on Twitter @atrupar.