In Giacomo Puccini’s La Bohème, the central romance between aspiring poet Rodolfo and ailing seamstress Mimi offers a sweeping love story with a cathartic dose of mortal fragility. Though the impoverished artists who populate the work would have been called bohemians, contemporary audiences will recognize these personalities in every young person doggedly resisting the comforts of a nine-to-five lifestyle for an artistic calling. The potent pairing of relatable yearnings with Puccini’s lofty score has established La Bohème as one of the most widely accessible operas of modern times. This latest Michael Christie-conducted presentation for the Minnesota Opera features a world-caliber cast of alternating leads. Sopranos Nicole Cabell and Miriam Khalil will take on the tragic part of Mimi, while tenors Scott Quinn and Adam Luther will trade off as her love-struck paramour, Rodolfo. St. Paul native William Lee Bryan will alternate with Edward Parks in the baritone part of devoted friend Marcello, while Minnesota-born singer Alexandra Razskazof switches up with first-year resident artist Mary Evelyn Hangley as the flirtatious Musetta.